Kazuhiro Tanabe

Kyushu Pro Search Limited Liability Partnership, Yokohama, Kanagawa 227-8502, Japan

Publications
  • Research Article   
    Purification of Syncytia-Producing Peptide as a Potential Therapeutic Agent for Cancer and Viral Infection
    Author(s): Michiko Koga*, Xiang-Guo Zheng, Manabu Watanabe, Sakiko Sato and Kazuhiro Tanabe

    Virus-induced syncytium formation, or cell fusion, has been investigated as a potential therapeutic approach for cancer. HVJ virus infection or transfection of membrane glycoproteins of virions have been known to cause syncytium formation in affected cells. Also, it was known that other enveloped viruses such as Herpes viruses, leukaemia viruses induce cell fusion. However, substances or molecules that directly cause syncytium formation have not been identified to date. Here, we identify a peptide that efficiently induces syncytia and report its structure, as an actionable therapeutic agent for cancer and viral infection. We purified and identified the fusion factor from the exosomes of the cells infected with murine leukaemia virus but not producing viruses by column chromatography, mass spectrometry, and amino acid analyses. We confirmed the peptide purified fro.. View more»

    DOI: 10.35248/2157-7560.21.s13.002

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