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Jin D
Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
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Hepatoprotective Effect of S-ademetionine in the treatment of Intrahepatic Cholestasis through Farnesoid X Receptor Mechanism in Rats
Author(s): Mao H*, Jin D, Lu M, Jin S and Huang Y
S-ademetionine (AdoMet) had been extensively studied in several clinical studies to treat Intrahepatic Cholestasis (IHC). The exact mechanism of action of AdoMet to regulator bile acid is unknown. Farnesoid X Receptor (FXR), a multifunctional nuclear receptor, plays vital roles in metabolism of bile acid. This study aims to investigate the mechanism of action of S-ademetionine in FXR to treat IHC. The IHC Sprague Dawley (SD) rat model was developed by administering Alpha Naphthyl Isothiocyanate (ANIT, 50 mg/kg). FXR excitant GW4064 (3 mg/kg) was used as a control to observe the impact of AdoMet (60 mg/kg) on the changes in serum direct levels in these rats. The hepatic histology between the HE staining contrast groups was performed using the Q-PCR to test FXR and the in situ hybridization was used to test the changes of bile salt export pump (Bsep), multidrug resistance-assoc.. View more»