School of Life and Health Sciences, Aston University, B4 7ET, Birmingham, UK
Research Article
Increased Circulating Levels of Inflammatory Markers in A Cohort of Adults with Youth-Onset Type 2 Diabetes Mellitus
Author(s): Dr. Nadia Lascar, Islam Afzal, Prof. Alan Nevill, Kiran Shabir, Dr. Ioannis Kyrou, Dr. James Brown and Dr. Srikanth Bellary*
Background: Young-onset type 2 diabetes (T2DMY) is considered to have a more aggressive disease phenotype, unfavourable long-term outcomes, and a close association with low-grade chronic inflammation. The aim of this study was to explore the circulating inflammatory profile in a cohort of adults with T2DMY and assess its potential associations.
Methods: T2DMY adults (n=65) and non-diabetic controls (n=40) underwent detailed anthropometric and biochemical characterisation. Serum levels of six pro-inflammatory biomarkers (soluble E-selectin, IL-1β, IFN-γ, IL-6, IL-8 and angiopoietin like protein-4) were measured by Magnetic Luminex Assays and were compared between study groups. Potential associations of these biomarkers with anthropometric/biochemical parameters and microvascular complications were also tested in the T2DMY group. .. View More»
DOI:
10.35248/2155-6156.20.11.853
