Journal of Biomolecular Research & Therapeutics

Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan-60800, Pakistan

Publications

• Review Article   
  Recombinant Antibodies and Vaccines for Viruses
  Author(s): Iqbal RK* and Shabir S
  
  Immunity produced when variable, diverse, and joining exons recombine and form diverse B-cell receptors. Somatic rearrangement of immunoglobulin genes termed VDJ recombination. This activity is controlled by RAG1 and RAG2 proteins, binds to the signal sequences and start cleavage. Double stranded breaks are produced by ROS, Nuclear enzymes and ATM. RAG protein induces cleavage activity. Segments exchange by CSR. After cleavage activity shuffling of segments occurs. TDT cause gain or loss of nucleotide bases. AID and RAG begins the process of CSR that shuffle exons of constant region. The core of NHEJ have catalytic subunit (DNA-Pkcs). Ku-DNA complex is important for the attachment of nuclease, polymerase and ligase of NHEJ. RAG2 with histone H3K4Me3 start recombination activity. HMG1 and HMG2 promote synapsis and cleavage. RNA Helicase of the DExD\H induces conformational changes. ZnA.. View more»
  

  DOI: 10.35248/2167-7956.19.8.169

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