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Getu Ayele
Department of Veterinary Microbiology, College of Veterinary Medicine and Agriculture, University in Addis Ababa, Bishoftu, Ethiopia
Publications
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Review Article
Review on Recent Advance of Vaccine Adjuvants
Author(s): Getu Ayele*
Vaccines are the most feasible and cost-effective strategy for protecting, controlling and reducing infectious disease in both animal species and humans. Despite, the significant use of vaccines, formulation of effective and safe vaccine is needed to afford sufficient protection through usage of appropriate adjuvants. Adjuvants are chemicals, proteins or derivatives of microbial formulated with vaccines to enhance innate and adaptive immune response to vaccine antigens by a variety of mechanisms. The term adjuvant comes from Latin word “adjuvare” which means to help and discovered in early 1920s. Many molecules have been considered as an adjuvant including aluminium salts (alum), oil emulsions, saponins, ISCOMs, liposomes, VLPs, cytokines, combined adjuvants and derivatives of bacteria are among in use and explored vaccine adjuvants. Mainly they have b.. View more»