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Christopher Zarins
HeartFlow,Inc. Redwood City, California, USA
Publications
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Research Article
Diagnosis and Treatment of Silent Coronary Ischemia May Reduce Adverse Cardiac Events and Improve Long-Term Survival of Patients Undergoing Lower-Extremity Revascularization
Author(s): Dainis Krievins*, Edgars Zellans, Gustavs Latkovskis and Christopher Zarins
Background: Patients with Peripheral Artery Disease (PAD) undergoing lower-extremity revascularization are at increased risk of death and Myocardial Infarction (MI) due to co-existing Coronary Artery Disease (CAD) which is often unrecognized due to absence of chest pain symptoms. A new cardiac diagnostic test, coronary CT-derived Fractional Flow Reserve (FFRCT), can identify patients with unsuspected (silent) coronary ischemia. We sought to determine whether pre-operative diagnosis of silent coronary ischemia using FFRCT can facilitate multidisciplinary care to reduce post-operative death and MI and improve survival of PAD patients. Methods: Symptomatic PAD patients with no cardiac history or symptoms were enrolled in a prospective, open-label study of coronary CTA and FFRCT testing before lower.. View more»