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Christopher A. Beaudoin
Dr, Department of Biochemistry, University of Cambridge, England, UK
Publications
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Short Communication
Antigenic Structural Similarity as a Predictor for Antibody Cross-Reactivity
Author(s): Christopher A. Beaudoin* and Tom L. Blundell
Antibodies are an essential component of the adaptive immune system that function to neutralize foreign invaders, such as bacterial and parasitic pathogens. However, B-cell epitopes remain difficult to predict due to their general indistinguishability from other protein regions. Epitope prediction tools in the past have largely relied on amino acid sequence similarity; however, implementing three-dimensional protein structure analyses into the epitope prediction algorithms has been shown to increase detection accuracy. Furthermore, structural comparisons between antigenic proteins for their potential to bind cross-reactive antibodies have not been explored extensively in the literature. Recent studies have pointed to the utility of looking at shared epitope structures in predicting antibody crossreactivity, which may shed light on cross-immunity between infectiou.. View more»