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Chellappagounder Thangavel
Department of Dermatology, University of Thomas Jefferson, Philadelphia, United States
Publications
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Review Article
Dark Side of Cancer Therapy: Cancer Treatment Induced Cardiopulmonary Inflammation Fibrosis and Immune Modulation
Author(s): Chellappagounder Thangavel*
Advancements in cancer therapy increased the cancer free survival rates and reduced the malignant related deaths. Therapeutic options for patients with thoracic cancers include the surgical intervention and combination of chemotherapy with ionizing radiation. Despite these advances, Cancer Therapy-Related Cardiopulmonary Dysfunction (CTRCPD) is one of the most undesirable side effects of cancer therapy. Chemo-radiation therapy or immunotherapy promote acute and chronic cardiopulmonary damage by inducing reactive oxygen species, DNA damage, inflammation, fibrosis, altering cellular immunity, cardiopulmonary failure, and non-malignant related deaths among cancer-free patients. CTRCPD is a complex entity with multiple factors involved in this pathogenesis. Although the mechanisms of cancer therapy induced toxicities are multifactorial, damage to the cardiac and pu.. View more»