Journal of Clinical & Experimental Pharmacology

Department of Pharmacy, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia

Publications

• Research Article   
  Evaluation of Antidiabetic and Antioxidant Potential of Hydromethanolic Seed Extract of Datura Stramonium in Mice
  Author(s): Bamlaku Cherie Melaku and Gedefaw Getnet*
  
  Background: Datura Stramonium Linn is one of the folkloric medicines in Ethiopia and demonstrated in vitro antidiabetic activity. Thus, the current study was carried out to evaluate antidiabetic activity of hydromethanolic seed extract in mice. Methods: The seed of Datura Stramonium was extract by using hydromethanol. The effect of the seed extract on blood glucose level was assessed after oral administration of 100, 200 and 400 mg/kg doses in normal, oral glucose loaded and Streptozocininduced diabetic mice. Antioxidant capacity of seed extract was evaluated by using a 2, 2-diphenyl-1-picrylhydrazyl assay. Results: Hypoglycemic effect of all doses of seed extract was insignificant (p>0.05) in normoglycemic model but glucose reduction was significant (p<0.05 at 100 mg/kg, p<0.. View more»
  

  Abstract HTML PDF