Yuvashree Muralidaran
India
Review Article
Diabetic Cardiomyopathy: A New Perspective of Mechanistic Approach
Author(s): Yuvashree Muralidaran and Pragasam ViswanathanYuvashree Muralidaran and Pragasam Viswanathan
Diabetic cardiomyopathy
(DCM), one among the macrovascular complications of diabetes is the leading cause of mortality around the globe. The emergence of DCM irrespective of other cardiovascular diseases (CVD) necessitates a deeper insight into its occurrence and mechanism of development. This review summarizes the different stages in DCM progression based on molecular, cellular and functional level. The early stage in DCM involves
oxidative stress
and endoplasmic reticulum stress concomitant with O-linked glycosylation of receptors, and extracellular matrix (ECM) proteins, and formation of advanced glycation end products (AGE). This further influences myocyte apoptosis and steatosis, which is followed by fibrosis and remodeling, thus altering the physiological functioning of heart. It has been postulated that, microbuminuria (MA) which is an indicator of.. View More»