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Yung Jolene YK
Yung Jolene YK
Hong Kong
Publications
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Review Article
Medical Implications of Antimicrobial Coating Polymers- Organosilicon Quaternary Ammonium Chloride
Author(s): Yuen John WM and Yung Jolene YKYuen John WM and Yung Jolene YK
Hospital-Associated Infections (HAI) are commonly caused by the invasive device and prosthesis implanted in the body. The practice of coating antimicrobial agents on biomedical surfaces or modifying the composite resin with such agents has been shown effective in reducing the incidence of HAI. Quaternary Ammonium Chloride (QAC) salts and the Organosilicon derivatives (OrganoSiQAC) are surface active to serve these applications. Clinically, Benzalkonium chloride (BAC) is effective against a board range of microorganisms. However, it has been recognized as the source of several hospital outbreaks due to contamination with gram-negative bacteria. Safety aspects such as potential toxicities and in vivo efficacies were poorly defined. On the other hand, physical antimicrobial polymers formed by OrganoSiQAC compounds were found to be chemically stable and nonleachable from the bonded surfac.. View More»
DOI: 10.4172/2329-6798.1000107