Yoshimitsu Kuroyanagi
Technosurg Ltd.,
5-4-30, Nishihashimoto, Midori-ku, Sagamihara, 252-0131
Japan
Case Report
Advanced Treatment of Burns and Skin Ulcers Using Tissue-Engineered Products
Author(s): Misato Kuroyanagi and Yoshimitsu KuroyanagiMisato Kuroyanagi and Yoshimitsu Kuroyanagi
Three types of tissue-engineered products have been introduced in this review. The first product is an allogeneic cultured dermal substitute. This product is manufactured by incorporating allogeneic fibroblasts into a spongy sheet of hyaluronic acid and collagen. Allogeneic fibroblasts are rejected gradually in immune system. However, they are able to release some growth factors that are essential for wound healing. Hyaluronic acid and collagen also have a potential to promote wound healing. The clinical study demonstrated that this cultured dermal substitute is useful for the treatment of burns and skin ulcers. The second product is a functional wound dressing. This product is manufactured by freeze-drying an aqueous solution of hyaluronic acid, collagen, and epidermal growth factor. Epidermal growth factor has a potential to promote wound healing by enhancing both keratinocyte and f.. View More»
