Journal of Liver

Yong-Ping Chen

Publications

• Research Article
  Pharmacotherapy for Hepatic encephalopathy: view of Evidence-Based Medicine
  Author(s): Ming-Hua Zheng, Dan-Qin Sun, Qian Jiang, Ke-Qing Shi, Ai-Min Wu and Yong-Ping ChenMing-Hua Zheng, Dan-Qin Sun, Qian Jiang, Ke-Qing Shi, Ai-Min Wu and Yong-Ping Chen
  
  Hepatic encephalopathy (HE) refers to a complex and reversible neuro-psychiatric syndrome that results from complications of acute or chronic hepatic failure, particularly alcoholic cirrhosis. It will lead to frequent life disruptions, poor quality of life and extensive use of health care resources. We conducted the review of several agents based on randomized controlled trials (RCTs) of high-quality Jadad scores (≥3) to provide effective information for clinical practice. Rifaximin appears at least to be as effective as conventional treatments, but not superior to them. L-Ornithine-L-aspartate appears to be a safe and effective treatment of chronic HE when compared with a placebo regime. Other treatments include non-absorbable disaccharides (NAD) and benzodiazepine receptor antagonists. In spite of the variability in the improvement of HE, NAD and non-absorbed antibiotics such as .. View More»
  DOI: 10.4172/2167-0889.1000102

  Abstract PDF