Yasuo Ido
Tanzania
Review Article
Linking Diabetic Complications to Sorbitol Oxidation, Oxidative Stress and Metabolic Suppression
Author(s): Joseph R Williamson and Yasuo IdoJoseph R Williamson and Yasuo Ido
Significance: Numerous clinical trials implicate a key role for hyperglycemia in the pathogenesis of diabetic complications. Recent studies support the importance of oxidative stress in mediating these complications. Although it is well known that hyperglycemia increases the rates of glucose metabolism via glycolysis and the sorbitol pathway, the importance of their contributions to oxidative stress and diabetic complications remains controversial.
Recent advances and critical issues: The major objectives of this review are to draw attention to: 1) recent advances supporting the importance of oxidative stress linked to increased sorbitol oxidation in fueling oxidative stress evoked by hyperglycemia, 2) important caveats to interpretations of experimental observations using flawed experimental protocols and methods and/or inappropriate surrogate animal models of diabetes (i.e. g.. View More»
