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Yang Wan-Hua
Yang Wan-Hua
IR Iran
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Research Article
P-gp Induction by Curcumin: An Effective Antidotal Pathway
Author(s): He Juan, Tang Jing, Yang Wan-Hua, Song Juan, Liu Xiao-Lei and Peng Wen-XingHe Juan, Tang Jing, Yang Wan-Hua, Song Juan, Liu Xiao-Lei and Peng Wen-Xing
Aim: We had reported that low dose curcumin could reduce the absorption of talinolol. The investigation in this study provided more information about inductive effect of high dose curcumin and further elucidated the mechanism between curcumin and drug interactions mediated by intestinal p-gp. Methods: The pharmacokinetics of talinolol after high dose curcumin was studied in 12 healthy volunteers using HPLC-MS/ESI method. The function, expression and mRNA levels of p-gp were determined in p-gp over-expressing caco-2 cells by flowcytometry or real-time quantitative polymerase chain reaction. Results: High dose curcumin decreased the AUC0-∞ and Cmax of talinolol by 42% and 29%, respectively, CL/F was significantly increased by approximately 77% versus control. In vitro studies, curcumin and its metabolite tetrahydrocurcumin significantly upregulated function, expression and MDR1 mR.. View More»
DOI: 10.4172/jbb.1000165