Journal of Thrombosis and Circulation: Open Access

Xue A

Publications

• Research Article
  In vitro Analysis of the Hemostatic Properties of Whole Blood Products Prepared with a Platelet-Sparing Leukoreduction Filter
  Author(s): Zielinski MD, Stubbs JR, Polites SF, Xue A, Haugen DAL, Emery R, Jenkins DH and Park MSZielinski MD, Stubbs JR, Polites SF, Xue A, Haugen DAL, Emery R, Jenkins DH and Park MS
  
  Background: Warm fresh whole blood (WFWB) is an ideal resuscitation fluid for exsanguinating patients but there are myriad logistic and infectious issues associated with its use. Cold whole blood (CWB) may be an acceptable alternative to the reconstituted whole blood (RWB), the current standard of care. A leukoreduction filter has been developed which maintains platelet count while eliminating white blood cells but its effect on platelet function is unknown. We hypothesize that CWB will retain an acceptable functional coagulation profile after filtration and over time. Study Design and Methods: WFWB and CWB samples were obtained from eight donors and four units of RWB were created. The quantitative and qualitative in vitro coagulation profiles of WFWB, RWB, and CWB over time were compared. Results: Filtration was successful at removing white bl.. View More»
  DOI: 10.4172/2572-9462.1000124

  Abstract PDF