Xiao-nan Ruan
Pudong New Area Centers for Disease Control and Prevention,
3039 Zhang Yang Road, Shanghai 200136
Bolivarian Rep. of Venezuela
Research Article
Association of CDKAL1 Genetic Polymorphism with Glycosylated Hemoglobin A1c Level among Non-Diabetic Chinese Adults
Author(s): Jun-yi Jiang, Hua Qiu, Gen-ming Zhao, Yi Zhou, Miao Mo, Le Shu, Lu-xi Yang, Si-yu Yu, Qing-wu Jiang, Xiao-nan Ruan and Wanghong XuJun-yi Jiang, Hua Qiu, Gen-ming Zhao, Yi Zhou, Miao Mo, Le Shu, Lu-xi Yang, Si-yu Yu, Qing-wu Jiang, Xiao-nan Ruan and Wanghong Xu
Objectives: Multiple single nucleotide polymorphisms (SNPs) have been identified as risk loci for type 2 diabetes (T2DM). This study was conducted to increase our understanding of the mechanisms through which three novel risk variants affect the risk of T2DM. Methods: 918 Chinese volunteers from Pudong New Area of Shanghai, China, were recruited in Oct-Dec, 2006. Collection of demographic and lifestyle characteristics, body measurements, bio-specimen collection and biochemistry assays were performed during the period. Genotyping of rs290487 at transcription factor 7-like 2 (TCF7L2), rs9465871 at cyclin-dependent kinase 5 regulatory subunit associated protein 1-like 1(CDKAL1) and rs1359790 at chromosome 13q31.1 were conducted using Taqman approach. Results: Genotypes of TCF7L2-rs290487, CDKAL1-rs9465871 and rs1359790 at 13q31.1 were not associated with metabolic syndrome or its compone.. View More»
