Journal of Blood Disorders & Transfusion

Xiaofan Li

Publications

• Case Report
  Recovery from Cidofovir-Resistent BK Virus-Associated Hemmorhagic Cystitis Post Cord Blood Transplant Following Rapid Taper of Immunosuppression
  Author(s): Xiaofan Li, Haiying Fu, Nainong Li, Jianda Hu and Yuanzhong ChenXiaofan Li, Haiying Fu, Nainong Li, Jianda Hu and Yuanzhong Chen
  
  Hemorrhagic cystitis (HC) usually happens 2-4 weeks after Hematopoietic Stem Cell Transplantation (HSCT). BK virus associated HC is a severe complication after HSCT and usually sensitive to cidofovir treatment. Here we report a late onset BK virus-associated HC after a cord blood transplantation (HLA 5/6) followed by a failure treatment of cidofovir in an acute lymphoblastic leukemia patient. The patient was conditioned with an intensified conditioning regimen containing fludarabine, cytosine arabinoside, busulfan, cyclophosphamide and rabbit antithymocyte globulin (FABuCy+ATG). The late development of HC with the symptom of hematuria occurred 22 days after HSCT and was associated with BK virus. In two weeks, the hematuria progressed with the failure of hydration, alkalizing diuresis and reduction of immunosuppressant treatment. Surprisingly, treatment of cidofovir only transient lowe.. View More»
  DOI: 10.4172/2155-9864.1000348

  Abstract PDF