Xi Chen

Xi Chen
Harvard School of Public Health,
Boston, Massachusetts 02115
Tanzania

Publications
  • Review Article
    With or Without them: Essential Roles of Cofactors in ES Cells
    Author(s): Hui Ma, Jin Rong Ow, Xi Chen and Qiang WuHui Ma, Jin Rong Ow, Xi Chen and Qiang Wu

    Embryonic stem cells (ESCs) are pluripotent cells which are capable of differentiating into many cell types. A complex transcriptional network consisting of Oct4, Sox2 and Nanog maintains ESCs in undifferentiated state while being poised to be directed into different committed cell types. Recently, tremendous efforts have made to elucidate the functions of cofactors in ESC identity and differentiation. More and more evidence has shown that cofactors are crucial for both pluripotency maintenance and differentiation capacity in ESCs. Cofactors do not bind to DNA directly. Rather, they are usually recruited to target sites by transcription factors or epigenetic marks. Transcriptional cofactors including coactivators or corepressors serve as critical components of the regulatory circuitry that ensures unique gene expression program in ESC.. View More»
    DOI: 10.4172/2157-7633.S10-006

    Abstract PDF