Journal of Clinical & Experimental Pharmacology

Wiroon Laupattarakasem

Publications

• Research Article
  Determination of Cartilage Volume Using MRI in Patients with Knee Osteoarthritis: Efficacy Study of 25 Milligrams of Sodium Hyaluronate (2.5 Ml) Versus Placebo
  Author(s): Weerachai Kosuwon, Winai Sirichatiwapee, Tweechock Visanuyotin, Polasak Jeeravipoolvarn and Wiroon LaupattarakasemWeerachai Kosuwon, Winai Sirichatiwapee, Tweechock Visanuyotin, Polasak Jeeravipoolvarn and Wiroon Laupattarakasem
  
  Background: Osteoarthritis (OA) of the knee is prevalent and associated with both pain and functional disability. Visco-supplementation is an intra-articular therapeutic modality for the treatment of knee OA, based on the physiologic importance of hyaluronan in synovial joints. The therapeutic goal is to restore the viscoelasticity of synovial hyaluronan, decrease pain, improve mobility and restore the natural protective functions of hyaluronan in the joint radiography is currently the most widely used modality for assessing damage in OA: this technique allows the measurement of joint space width (JSW) the appropriate primary endpoint for demonstration of efficacy. There are, however, questions regarding its validity and reliability. Magnetic resonance imaging (MRI) with its superior soft tissue contrast is the best technique available for assessment of normal articular cartilage and car.. View More»
  DOI: 10.4172/2161-1459.1000112

  Abstract PDF