Journal of Clinical & Experimental Pharmacology

William R Ravis

Publications

• Research Article
  Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats
  Author(s): Yuh-Jing Lin, Yann-Huei Phillip Lee and William R RavisYuh-Jing Lin, Yann-Huei Phillip Lee and William R Ravis
  
  Objectives: To investigate the pharmacokinetics of Carbamazepine (CBZ) in rats during growth hormone treatment. Methods: Recombinant Human Growth Hormone (rhGH) was injected subcutaneously at a daily dose of 0.1 mg/ kg, 2 mg/kg, or phosphate buffered saline (control) for 5 days in male Sprague-Dawley rats. On day 6, a dose of 25 mg/kg of CBZ was injected intravenously via a jugular vein cannula into the rat. Growth rate were compared between treatment groups. The pharmacokinetics of CBZ was determined from its concentrations in rats? blood and urinary samples. Results: Over the 5-day treatment period, growth rate were greater than control for the 2 mg/kg rhGH dosed group. The volume of distribution (Vss) was significantly (p.. View More»
  DOI: 10.4172/2161-1459.1000132

  Abstract PDF