Wambua KF
Kenya
Research Article
Hypoglycemic Effect of Lippia javanica in Alloxan Induced Diabetic Mice
Author(s): Arika WM, Abdirahman YA, Mawia MM, Wambua KF, Nyamai DM, Ogola PE, Kiboi NG, Nyandoro HO, Njagi SM, Agyirifo DS, Ngugi MP and Njagi ENMArika WM, Abdirahman YA, Mawia MM, Wambua KF, Nyamai DM, Ogola PE, Kiboi NG, Nyandoro HO, Njagi SM, Agyirifo DS, Ngugi MP and Njagi ENM
Lippia javanica is widely distributed throughout Kenya where it is used extensively in traditional herbal preparations. An infusion of the leaves is commonly used as a decongestant for colds and coughs including diabetes, however, its efficacy profiles have not been scientifically evaluated. The aim of this study was to determine the in vivo antidiabetic activity of aqueous leaf extracts of this plant in white male alloxan-induced albino mice. The antidiabetic activity of the aqueous leaf extracts was orally and intraperitoneally bioscreened in alloxan induced diabetic mice at different doses of 25 mg/kgbwt, 48.4 mg/kgbwt, 93.5 mg/kgbwt, 180.9 mg/kgbwt and 350 mg/kgbwt. The treatment effects were then compared with the controls. Phytochemical composition was assessed using standard procedures. The extract showed hypoglycemic activity at dose levels of 25, 48.4, 93.5, 180.9 and 350 mg/.. View More»
