Journal of Clinical & Experimental Pharmacology

Journal of Clinical & Experimental Pharmacology
Open Access

ISSN: 2161-1459

+44 1202068036

Vivek Kumar Dwivedi

Vivek Kumar Dwivedi
Venus Medicine Research Centre,
Hill Top Industrial Estate, Bhatoli Kalan, Baddi, H.P. - 173205

  • Research Article
    Comparative Study of CSE 1034 and Ceftriaxone in Pneumonia Induced Rat
    Author(s): Vivek Kumar Dwivedi, Gagan Goswami and Manu ChaudharyVivek Kumar Dwivedi, Gagan Goswami and Manu Chaudhary

    Pneumonia caused by Klebsiella pneumoniae is important due to its high morbidity and mortality. This infection causes acute inflammation in the lung due to characterized by increased activity of neutrophils, generate oxy free radical and decreased the endogenous anti oxidant defense system. CSE1034 is a novel fixed dose combination drug of ceftriaxone plus sulbactam with VRP1034. The aim of this investigation was to compare the efficacy study of CSE1034 drug vs ceftriaxone alone in pneumonia induced rat model. For pneumonia infection in animal model, doses were standardized at concentration 102 to 106 CFU/ml of Klebsiella pneumoniae. Total thirty two male rats (150 5 g) were randomely selected and divided into four groups of eight animals each. Group I was normal saline treated; group II was pneumonia infected; group III was infected plus ceftriaxone treated and group IV was infected p.. Read More»
    DOI: 10.4172/2161-1459.1000108

    Abstract PDF

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