Mini Review
Calcium Transport across Plasma Membrane in Early Stages of Chronic Kidney Disease Impact of Vitamin D3 Supplementation
Author(s): Ingrid Lajdova and Viera SpustovaIngrid Lajdova and Viera Spustova
Mini review summarizes the results of studies focused on elucidating pathophysiological mechanisms of altered intracellular calcium homeostasis in the peripheral blood mononuclear cells of patients with early stages of chronic kidney disease. The basic mechanisms of calcium entry as well as those of its removal are impaired by the disease. These disturbances cause an increase concentration of free cytosolic calcium which can result in a change of broad range of cellular processes and expression patterns of various signaling molecules. Vitamin D3 supplementation is the standard treatment of frequent vitamin D3 insufficiency or deficiency in these patients. It can be assumed that vitamin D3 through the pleiotropic effects may participate in modulation of intracellular c.. View More»
