Viera Lukacova
Tanzania
Research Article
Modelling the Absorption of Metformin with Patients Post Gastric Bypass Surgery
Author(s): May Almukainzi, Viera Lukacova and Raimar LöbenbergMay Almukainzi, Viera Lukacova and Raimar Löbenberg
Purpose: Gastric bypass surgery in obesity shortens the length of the small intestine, which can have a significant impact on drug absorption. Literature reports that the observed drug absorption patterns after gastric bypass surgery are sometimes unexpected. One report states that the absorption of Metformin was higher after gastric bypass surgery. The purpose of this study was to investigate the mechanistic background of the reported data using Advanced Compartmental Absorption and Transit (ACAT™) model and apply it to patient data with post gastric bypass surgery.
Methods: GastroPlus™ 8 (Simulations Plus, Inc.) was used to develop a model that describes the observed absorption of an immediate release (IR) metformin tablet in healthy subjects. The data was taken from a published article that compared the absorp.. View More»
