Biochemistry & Analytical Biochemistry

Vani Priyadarshini I

Publications

• Research Article
  Identification of Putative Drug Targets and Vaccine Candidates for Pathogens Causing Atherosclerosis
  Author(s): Kanipakam Hema, Vani Priyadarshini I, Dibyabhaba Pradhan, Manne Munikumar, Swargam Sandeep, Swargam Sandeep, Natarajan Pradeep, Suchitra MM and Amineni UmamaheswariKanipakam Hema, Vani Priyadarshini I, Dibyabhaba Pradhan, Manne Munikumar, Swargam Sandeep, Swargam Sandeep, Natarajan Pradeep, Suchitra MM and Amineni Umamaheswari
  
  Atherosclerosis is a chronic inflammatory artery disease, responsible for both cardiovascular (heart) and cerebrovascular (brain) stroke with high morbidity and mortality worldwide. Infectious pathogens such as Chlamydophila pneumoniae, Porphyromonas gingivalis and Helicobacter pylori are shown to be associated with the disease in recent epidemiological studies. Therefore, identification of common drug targets and vaccine candidates against these three pathogens would be vital towards therapy and management of atherosclerosis. Chlamydophila pneumonia was selected as a reference organism due to its predominant role in atherosclerosis. Implementing comparative genomic approach, subtractive genomic approach, metabolic pathway analysis, non-homologous gut flora analysis and domain search analysis, 35 common putative drug targets were identified against pathogens of athero.. View More»
  DOI: 10.4172/2161-1009.1000175

  Abstract PDF