Vaia Lambadiari
Research Institute and Diabetes Center,
“Attikon” University Hospital, Rimini Street, GR-12462 Haidari
Greece
Research Article
Short Term, Low Dose Thyroxin Treatment of Euthyroid Patients with Type 2 Diabetes improves Peripheral Blood Flow and Overall Insulin Sensitivity
Author(s): Vaia Lambadiari, Filio Spanoudi, Eirini Maratou, Evangelina Vassilatou, Erifili Hatziagelaki, Panagiota Mitrou, George Matsangouras and George DimitriadisVaia Lambadiari, Filio Spanoudi, Eirini Maratou, Evangelina Vassilatou, Erifili Hatziagelaki, Panagiota Mitrou, George Matsangouras and George Dimitriadis
Purpose: Variation of plasma thyroid hormone levels influences insulin sensitivity and peripheral glucose disposal. High thyroxin dose administration to healthy humans induces insulin resistance, whereas moderate doses increase peripheral glucose disposal. An open-labeled, randomized and placebo-controlled intervention was performed in euthyroid type 2-diabetic patients, to examine the effect of a small thyroxin dose within the euthyroid range on postprandial forearm muscle glucose uptake, insulin sensitivity, in vitro glucose uptake and GLUT4 recruitment in the plasma membrane of monocytes. Methods: A meal was given to eleven euthyroid, treatment-naive, type-2 diabetic patients (aged 43 ± 3.8 yrs, BMI 27.48 ± 1.39 kg/m2, T3 119 ± 5.7 ng/dl, T4 8,13 ± 0.46 μg/dl, TSH 1.51 ± 0.14 μU/ml, FT4 1.272 ± 0.047 ng/dl) before and.. View More»
