Urban Osby
Sweden
Research Article
Genes Associated with Increased Fasting Glucose in Patients with Schizophrenia Spectrum Disorders
Author(s): Dzana Sudic Hukic, Eric Olsson, Agneta Hilding, Claes-Goran Ostenson, Harvest F Gu, Ewa Ehrenborg, David Erlinge, Gunnar Edman, Martin Schalling, Catharina Lavebratt and Urban OsbyDzana Sudic Hukic, Eric Olsson, Agneta Hilding, Claes-Goran Ostenson, Harvest F Gu, Ewa Ehrenborg, David Erlinge, Gunnar Edman, Martin Schalling, Catharina Lavebratt and Urban Osby
Background: Metabolic risk factors represent a major cause of increased coronary heart disease morbidity and mortality among psychosis patients. Although antipsychotic medication may lead to hyperglycemia, an association to severe mental illness was established before the introduction of antipsychotics.
Methods: We investigated the association between metabolic risk genes and elevated fasting glucose level in patients with schizophrenia spectrum disorder. We applied two association models; (i) case-case where psychosis patients with elevated fasting glucose level (≥5.6 mmol/l) or diagnosed diabetes (n=263) were compared to patients with normal glucose level (n=389), and (ii) case-control model where psychosis patients with elevated fasting glucose level were compared to population-derived controls (n=494). Association analyses were adjust.. View More»
