Journal of Liver

Umberto Cillo

Publications

• Review Article
  Could Sorafenib Disclose New Prospects as Bridging Therapy to Liver Transplantation in Patients with Hepatocellular Carcinoma?
  Author(s): Alessandro Vitale, Freddy Salinas, Giacomo Zanus, Giuseppe Lombardi, Marco Senzolo, Francesco Russo and Umberto CilloAlessandro Vitale, Freddy Salinas, Giacomo Zanus, Giuseppe Lombardi, Marco Senzolo, Francesco Russo and Umberto Cillo
  
  Background-Aim: There are few data on the use of sorafenib as bridging therapy for patients with Hepatocellular Carcinoma (HCC) waiting for Liver Transplantation (LT). Methods: Six HCC patients were treated with sorafenib before LT at our Institution following the Italian Drug Agency guidelines: they had well compensated cirrhosis (Child-Pugh class A), intermediate stage HCC, good general conditions (performance status 0) and they were not suitable for loco-regional therapies. Results: Three patients received sorafenib until LT, whereas the other three cases required treatment discontinuation before LT. During the post-surgery period no deaths and anastomotic complications were observed. The four patients receiving Sorafenib for more than 2 months before LT were recurrence-free 27 to 41 months after surgery. Conversely, tumor recurrence leading to patient death was found in the other .. View More»
  DOI: 10.4172/2167-0889.1000134

  Abstract PDF