Biochemistry & Analytical Biochemistry

Tumelo Hendrick Tabane

Publications

• Research Article
  A Novel Molecularly Imprinted Polymer for the Selective Removal of Interfering Hemoglobin Prior to Whole Blood Analysis
  Author(s): Tumelo Hendrick Tabane and Bareki Shima BatlokwaTumelo Hendrick Tabane and Bareki Shima Batlokwa
  
  A heavy red globular protein, hemoglobin, responsible for whole blood red pigmentation often interferes with the identification and quantification of disease associated biomarkers from whole blood, in field of molecular diagnosis. The main challenge is the direct introduction of whole blood as a sample into analyzing instruments because of its physiological complexity and `dirty` nature. For example, the red pigment in whole blood, which is characterized as ‘dirt’, usually co-elute with the biomarkers and masks them from easy chromatographic separation prior to their final detection. It also clogs the instrument’s components such as the separating columns which are known to be sensitive, hence leading to imprecise and inaccurate results during bio-assaying. To address these challenges, our lab synthesised a novel, selective, effective and a robust hemoglobin imprinte.. View More»
  DOI: 10.4172/2161-1009.1000315

  Abstract PDF