Timori NH

Timori NH

West Indies

Publications
  • Research Article
    Quality Control of Platelets Concentrates; an In Vitro Fate Prediction Model System of PCs Transfusion
    Author(s): Timori NH and Badlou BATimori NH and Badlou BA

    Introduction: We previously described that metabolic resting preserves old and cold platelets (PLTs) concentrates (PCs). In Badlou et al. 2006 we have established that P-selectin involved as an intermediate in binding, and the combination of PS exposure with (-out) changes in GPIb in phagocytosis of PCs. Using a standard threshold over the interaction between donors PLTs and patient’s phagocytes might increase success of transfusion, and decrease side effects, pretransfusion. The aim of this study is to introduce a novel method, which could be used as an in-vitro prediction model system to envisage PCs fate, posttransfusion. Materials and Methods: Human PCs were stored for different periods to obtain a wide range of surface expressed P-selectin and-PS exposure. The quantitative change in GPIb was deduced from decreased bindin.. View More»
    DOI: 10.4172/2155-9864.1000275

    Abstract PDF