Tara Higgins

Tara Higgins

Tanzania

Publications
  • Research Article
    Impact of Malignancy Category on Vancomycin Dosage Requirements in Pediatric Oncology Patients
    Author(s): Kyle A Franco and Tara HigginsKyle A Franco and Tara Higgins

    Objectives: To determine the dosage of vancomycin in milligrams/kilogram/day (mg/kg/day) required to achieve a trough value of 10 to 20 micrograms/milliliter (mcg/mL) in pediatric patients with differing types of malignancies. Methods: Retrospective review of pediatric patients with hematologic malignancy, solid tumor, or status post autologous or allogeneic hematopoietic stem cell transplantation (HSCT) receiving at least two doses of intravenous vancomycin with at least one evaluable trough concentration. Primary outcome was the dosage of vancomycin required to achieve first therapeutic trough value. Secondary endpoints included dosage requirement by age, proportion of patients achieving goal, incidence of supratherapeutic trough values and nephrotoxicity. Results: Mean dosage requirements were 72.5 [&.. View More»
    DOI: 10.4172/2329-6887.1000238

    Abstract PDF