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Subas ch. Parija
Subas ch. Parija
College of Veterinary Sciences and Animal Husbandry,
Bhubaneswar- 751003
India
Publications
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Research Article
Pharmacokinetic Profile of Nimesulide in Bovine Calves
Author(s): Lombodar Mahapatra, Gyana R. sahoo, Monoj K. Panda and Subas ch. ParijaLombodar Mahapatra, Gyana R. sahoo, Monoj K. Panda and Subas ch. Parija
The aim of the present study was to investigate pharmacokinetic profile and bioavailability of cyclooxygenase (COX)-2 selective nonsteroidal anti-infalmmatory drug nimesulide in bovine male calves after intravenous (i.v.) and intramuscular (i.m.) administration at a dose of 4.5mg/ kg BW. Blood samples were collected by jugular venipuncture at predetermined times following drug administration. Nimesulide in the plasma was assayed by using a validated HPTLC method. Plasma concentration-time data were subjected to compartmental analysis and pharmacokinetic parameters for nimesulide after i.v. and i.m. administration were calculated according to two and onecompartment open models, respectively. Following i.v. administration, a rapid distribution phase was followed by slower elimination phase. The half-lives during distribution phase (t1/2α) and terminal elimination phase (t1/2β.. View More»
DOI: 10.4172/jbb.1000019