Steen Bønløkke Pedersen
Denmark
Research Article
Dysregulation of Zinc and Iron Balance in Adipose Tissue from Diabetic Sand Rats (Psammomys obesus)
Author(s): Trine Maxel, Rasmus Pold, Agnete Larsen, Steen Bønløkke Pedersen, Dorthe Carlson, Bidda Rolin, Thóra Brynja Bödvarsdóttir, Sten Lund, Jørgen Rungby and Kamille SmidtTrine Maxel, Rasmus Pold, Agnete Larsen, Steen Bønløkke Pedersen, Dorthe Carlson, Bidda Rolin, Thóra Brynja Bödvarsdóttir, Sten Lund, Jørgen Rungby and Kamille Smidt
Background: In obesity, the distribution and metabolic function of adipose tissue are of vast importance for the risk of type 2 diabetes development. The homeostasis of zinc and iron is believed to be disturbed in diabetic patients. Zinc dyshomeostasis could affect the metabolic function of adipose tissue as zinc is known to facilitate the functions of insulin within adipose tissue as well as take part in cell proliferation and apoptosis. Further, altered iron levels have been shown to affect insulin sensitivity. This study investigates the intracellular zinc regulation and total zinc and iron status in adipose tissues in obesity-linked, type 2 diabetes in the Psammomys obesus model.
Methods: Subcutaneous and visceral adipose tissue were collected from diabetic (n=6) and non-diabetic animals (n=6). Total zin.. View More»
