Advances in Pharmacoepidemiology and Drug Safety

Srinivasan Dasarathy

Publications

• Review Article
  Pharmacologic Management of Non-Alcoholic Fatty Liver Disease
  Author(s): George Boon-Bee Goh, Srinivasan Dasarathy and Arthur McCulloughGeorge Boon-Bee Goh, Srinivasan Dasarathy and Arthur McCullough
  
  Background: Non-alcoholic fatty liver disease (NAFLD) is a common complex chronic liver disease that encompasses a spectrum of disease from simple steatosis to non-alcoholic steatohepatitis (NASH). NASH has the potential to progress to advanced fibrosis and cirrhosis and is associated with increased morbidity and mortality. Currently, there are no definitive universally accepted treatment options available for NASH. Most pharmacological agents that have been investigated are limited by inconsistent efficacy or side effects. We reviewed the current literature on the principle drugs that have been tested for NAFLD in the adult population, with special emphasis on clinical data and safety profiles. Methods: A comprehensive PUBMED/MEDLINE search was conducted to identify principal therapeutic intervention studies for NAFLD, from which a summary of the studies were formula.. View More»
  DOI: 10.4172/2167-1052.1000157

  Abstract PDF