Journal of Pharmacovigilance

Srinivas

Publications

• Research Article
  Design and Evaluation of a Controlled Release Drug Delivery System for Management of Rheumatism
  Author(s): Santhosh Kumar, Anusha G, Rajyalaxmi, Srinivas and ManojSanthosh Kumar, Anusha G, Rajyalaxmi, Srinivas and Manoj
  
  The present research was aimed to design, formulate and evaluate Mucoadhesive colon targeted microspheres of Ketoprofen for many advantages especially increased bioavailability and reduction in dosing frequency etc. Ketoprofen is a NSAID, like other drugs in this group reduces pain, inflammation and stiffness in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. In this study an attempt was made to prepare mucoadhesive microspheres of Ketoprofen using the natural polymers designed for oral controlled release. Ketoprofen microspheres were prepared following 32 full factorial designs with varying concentrations of the polymers using sodium alginate and natural polymer such guar gum, xanthan gum by orifice-ionic gelation method. The prepared ketoprofen microspheres were evaluated for surface morphology and particle shape, rheological studies. Micro encapsulation e.. View More»
  DOI: 10.4172/2329-6887.1000234

  Abstract PDF