Solomon Assefa
School of Pharmacy,
P.O. Box 1176, Addis Ababa
Ethiopia
Research Article
Antimalarial Potential of the Leaf Exudate of Aloe macrocarpa Todaro and its Major Constituents against Plasmodium berghei
Author(s): Yitagesu Tewabe and Solomon AssefaYitagesu Tewabe and Solomon Assefa
Background: Aloe macrocarpa Todaro is one of the Aloe species in Ethiopia where its leaf exudate is traditionally used for the treatment of various ailments, including malaria.
Methods: Two pure compounds namely aloin and aloinoside were isolated from the leaf exudate. Further oxidative hydrolysis yielded another compound (aloe-emodin). Four-day suppressive test was employed to evaluate the antimalarial potential of the leaf exudates and isolated compounds as well as aloe-emodin against mice infected with Plasmodium berghei.
Results: The leaf exudate of A. macrocarpa showed significant chemosuppression of P. berghei at all dose levels tested compared to the negative control group. At a dose of 400 mg/kg, the leaf exudate of A. macrocarpa, the isolated aloin as well as the semi.. View More»
DOI:
10.4172/2161-1459.1000245