Journal of Clinical & Experimental Pharmacology

Shivapriya Shivakumar

Publications

• Research Article
  Effect of a Novel Polyherbal Formulation on Diabetes Induced Memory Deficits in Rats
  Author(s): Prabhat Upadhyay, Ananya Sadhu, Suresh Purohit, Praveen K Singh, Shivapriya Shivakumar, Aruna Agrawal, K. Ilango and Govind Prasad DubeyPrabhat Upadhyay, Ananya Sadhu, Suresh Purohit, Praveen K Singh, Shivapriya Shivakumar, Aruna Agrawal, K. Ilango and Govind Prasad Dubey
  
  Abstract Epidemiological, clinical and experimental studies have shown a strong correlation between Diabetes mellitus (DM) and neurodegenerative disorders. Type II diabetes mellitus (T2DM) leads to elevated levels of plasma glucose and causes neurological complications including impairment of learning and memory processes. The pathogenesis mainly includes metabolic dysfunction due to brain insulin resistance, oxidative stress, inflammation and vascular complications. In this study we explored a new pharmacological intervention by investigating the neuroprotective effects of a standardized polyherbal formulation (PF) [(Bacopa monnieri (20 mg/kg), Hippophae rhamnoides (25 mg/kg), and Dioscorea bulbifera (15 mg/kg), p.o] on passive avoidance learning (PAL) and memory in normal and streptozotocin (STZ) induced diabetic rats. Treatment was started after the onset of hyperglycemia following .. View More»
  DOI: 10.4172/2161-1459.1000194

  Abstract PDF