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Shigetaka Shimodaira
Shigetaka Shimodaira
Center for Advanced Cell Therapy, Shinshu University Hospital,
Matsumoto
Japan
Publications
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Perspective Article
Efficacy of Dendritic Cell-Based Cancer Immunotherapy
Author(s): Shigetaka Shimodaira, Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto and Shigeo KoidoShigetaka Shimodaira, Yumiko Higuchi, Ryu Yanagisawa, Masato Okamoto and Shigeo Koido
Dendritic cells (DCs) have antigen-specific bioactivity against tumor-associated antigens. The acquisition of tumor immunity with DC vaccination could be determined using both tetramer analysis and interferon γ-producing clones in enzyme-linked immunosorbent spot assays. A combination of DC vaccination with low-dose metronomic therapy and chemoradiotherapy would contribute to an enhanced acquired immunity for cancer therapy. The efficacy of DC vaccination may provide a survival benefit in some patients with cancer by achieving a prolonged quality-adjusted life year. .. View More»
DOI: 10.4172/2161-1009.1000240