Biology and Medicine

Shigeki Takaki

Publications

• Research Article
  Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model
  Author(s): Mariko Takenokuchi, Keiichi Kadoyama, Daisuke Yoshida, Shigeki Takaki, Ryoma Yamamoto, Katsuyasu Saigo and Taizo TaniguchiMariko Takenokuchi, Keiichi Kadoyama, Daisuke Yoshida, Shigeki Takaki, Ryoma Yamamoto, Katsuyasu Saigo and Taizo Taniguchi
  
  Introduction: Collagen exists in various connective tissues and helps to provide them mechanical strength and elasticity. The main component of the tendon is properly arranged collagen fibers withstanding very strong forces. The compactly packed collagen fine fibers inside the bone and cartilage increase their elasticity. Collagen also helps skin elasticity and strength. Hyaluronic acid widely exists in extracellular matrix, such as joints and skin. It plays an important role in maintaining cartilage function by making ultra-macromolecular complexes with aggrecan or protein. These collagen and hyaluronic acid decrease with age. Therefore oral supplementation or cosmetics containing them are developed day by day and catch interests of people trackleing anti-aging. The objective of this study was to evaluate and compare the absorbability of macromolecular substances in .. View More»
  DOI: 10.4172/0974-8369.1000448

  Abstract PDF