Journal of Clinical & Experimental Pharmacology

Shibeshi W

Publications

• Research Article
  Evaluation of the Antidepressant-like Activity of the Crude Extract and Solvent Fractions of Rosa Abyssinica Lindley (Rosaceae) Using Rodent Models of Depression
  Author(s): Fekadu N, Shibeshi W and Engidawork EFekadu N, Shibeshi W and Engidawork E
  
  Background: The fruit of Rosa abyssinica Lindley (Rosaceae) is claimed to alleviate depression in folkloric Ethiopian medicine. Nevertheless, the antidepressant-like effect has not been assessed in rodent models of depression. Methods: The test animals were randomly selected and divided into five groups (n = 8). Group I and II received 2% Tween 80 and the standard drug imipramine (30 mg/kg) respectively while Groups III to V received increasing doses of the extracts and duration of immobility at three dose levels of the crude extract and (100, 200, and 400 mg/kg) was the parameter determined to assess the antidepressant-like activity of R. abyssinica in tail suspension test (TST) and forced swimming test (FST). The locomotor activity was also evaluated in terms of number of square crossings using the open field test (OFT) in order to rule out possible psycho-stimulant activity. Results: .. View More»
  DOI: 10.4172/2161-1459.1000207

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