Journal of Aging Science

Shephali Bhatnagar

Publications

• Research Article
  Compatible Changes of Lead microRNAs in Circulating Plasma and Brain in Senescence-Accelerated Aging and Alzheimer's disease Mouse Models
  Author(s): Shephali Bhatnagar, Gregory J. Weber, Vikranth Shetty, Viktoriya Shekhovtsova and Eugenia WangShephali Bhatnagar, Gregory J. Weber, Vikranth Shetty, Viktoriya Shekhovtsova and Eugenia Wang
  
  Circulating microRNAs have recently emerged as powerful biomarkers because of their potential for monitoring changes in tissues such as the brain during aging. These microRNAs are found in many types of body fluids, and serve not only as systemic indicators of global and tissue-specific changes of gene expression, but also as functional mediators for cell-cell communication. In an effort to link changes in circulating microRNAs to changes in tissue, we used survival bleeding to perform comparative studies of three selected microRNAs, miR-34a, -34c, and -181b, in plasma and brain tissue in two types of animal models, Alzheimer’s Disease (AD) transgenic mutants and Senescence-Accelerated (SAMP8) mice. In this study, we show that expression of these microRNAs is altered in both AD and SAMP8 models, with comparable changes in expression of these specific microRNAs in both plasma and.. View More»
  DOI: 10.4172/2329-8847.1000125

  Abstract PDF