Seenivasan P

Seenivasan P

India

Publications
  • Case Report
    Amlodipine Induced Severe Pedal Edema: A Case Report from a Tertiary Care Hospital
    Author(s): Sanghavi K, Someshwari M, Rajanandh MG and Seenivasan PSanghavi K, Someshwari M, Rajanandh MG and Seenivasan P

    Amlodipine is a fourth generation dihydropyridine derivative calcium channel blocker, mainly used in the treatment of hypertension, angina and certain other cardiac disorders. It is an L-type Ca2+ channel blocker, which leads to inhibitory action on the sympathetic N-type Ca2+ channels. The oral bioavailability of amlodipine is between 64% and 90%. The longer duration of action of amlodipine is due to a combination of high bioavailability, slow clearance and long half-life where by plasma concentration of the drug is above minimum effective concentration for a long time and show sustained efficacy. The most frequently occurring adverse effect with amlodipine therapy includes palpitation, flushing, ankle edema, hypotension, headache and nausea. PedaPl edema is a common adverse effect of calcium channel blocker (Amlodipine, Nifedipine, Diltiazem, Felodpine, Isradipine). We report a pati.. View More»
    DOI: 10.4172/2329-6887.1000243

    Abstract PDF