Biochemistry & Analytical Biochemistry

Scott Nadeau

Publications

• Review Article
  Oncogenic Signaling by Leukemia-Associated Mutant Cbl Proteins
  Author(s): Scott Nadeau, Wei An, Nick Palermo, Dan Feng, Gulzar Ahmad, Lin Dong, Gloria E. O. Borgstahl, Amarnath Natarajan, Mayumi Naramura, Vimla Band and Hamid BandScott Nadeau, Wei An, Nick Palermo, Dan Feng, Gulzar Ahmad, Lin Dong, Gloria E. O. Borgstahl, Amarnath Natarajan, Mayumi Naramura, Vimla Band and Hamid Band
  
  Members of the Cbl protein family (Cbl, Cbl-b, and Cbl-c) are E3 ubiquitin ligases that have emerged as critical negative regulators of protein tyrosine kinase (PTK) signaling. This function reflects their ability to directly interact with activated PTKs and to target them as well as their associated signaling components for ubiquitination. Given the critical roles of PTK signaling in driving oncogenesis, recent studies in animal models and genetic analyses in human cancer have firmly established that Cbl proteins function as tumor suppressors. Missense mutations or small in-frame deletions within the regions of Cbl protein that are essential for its E3 activity have been identified in nearly 5% of leukemia patients with myelodysplastic/myeloproliferative disorders. Based on evidence from cell culture studies, in vivo models and clinical data, we discuss the potential signaling mechan.. View More»
  DOI: 10.4172/2161-1009.S6-001

  Abstract PDF