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Sami Dridi
Sami Dridi
University of Kentucky, College of Medicine, Bosomworth HSRB Rm 252, 1095 VA Drive, Lexington KY 40536,
Tanzania
Publications
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Research Article
Leptin and Cerulenin Differently Regulate Adiponectin Gene Expression in Chicken Liver and Hypothalamus
Author(s): Petra Sintubin, Eddy Decuypere, Johan Buyse, Arieh Gertler, Rebekah Whitfield and Sami DridiPetra Sintubin, Eddy Decuypere, Johan Buyse, Arieh Gertler, Rebekah Whitfield and Sami Dridi
Adiponectin and leptin are two adipocytokines originally found to be secreted mainly by white adipose tissue (AT) in mammals. They are involved in the control of energy homeostasis, body weight, lipid metabolism, and insulin sensitivity. The interplay between these two hormones was exclusively studied in mammals and yielded conflicting results. In birds, adiponectin and leptin are expressed not only in AT, but also in liver (for leptin) and in a wide range of tissues (for adiponectin). However, their physiological roles and relationship are still unknown. The aim of the present study was to investigate the effect of recombinant chicken leptin on adiponectin gene expression in three metabolically important tissues (liver, hypothalamus, and muscle). The effect of gender and cerulenin, the natural fatty acid synthase inhibitor which has.. View More»
DOI: 10.4172/1948-5948.1000054