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Journal of Data Mining in Genomics & Proteomics

Journal of Data Mining in Genomics & Proteomics
Open Access

ISSN: 2153-0602

Salina Y Saddick

Salina Y Saddick

Saudi Arabia

Publications
  • Research Article
    Association of G1691A Mutation in Women with Breast Cancer
    Author(s): Shaik Nazia Tabassum and Salina Y SaddickShaik Nazia Tabassum and Salina Y Saddick

     Objectives: More evidence indicates that the G1691A mutation in the factor V Leiden (FVL) gene might be associated with susceptibility to breast cancer in humans being. Breast cancer is gradually becoming the most common cancer in Indian women, pathogenesis can be influenced by single nucleotide polymorphisms and several studies in the past have identified different genetic variants in the human genome that showed strong or moderate evidence of associations. FVL is a missense mutation, result of an amino acid substitution of glutamine for arginine at 506 position in the factor V molecule at nucleotide 1691 substitutes G for A, resulting in a mutant protein resistant to the anticoagulant action of activated protein C. Methods: We aimed to investigate the role of G1691A mutation in FVL gene and breast cancer women from south Indian popula.. Read More»
    DOI: 10.4172/2153-0602.1000160

    Abstract PDF

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