Journal of Stem Cell Research & Therapy

Sahib Gul Afridi

Publications

• Research Article
  Therapeutic Potential of Selenium Treated Stem Cells for the Reduction of Liver Fibrosis
  Author(s): Sulaiman Shams, Muhammad Ayaz, Sahib Gul Afridi and Haider Ali KhanSulaiman Shams, Muhammad Ayaz, Sahib Gul Afridi and Haider Ali Khan
  
  Mesenchymal Stem Cells (MSCs) therapy is an alternative way to treat liver fibrosis. The aim of the current study is to enhance the therapeutic potential of MSCs by pretreated with selenium for the reduction of CCl4 induced liver injury. Male Balb/C mice were treated with CCl4 (1.0 μL/g) intraperitoneally, twice a week for 4 weeks. Mouse MSCs were cultured and then pretreated with 15 ng/ml selenium for 24 hrs. The untreated and selenium pretreated MSCs were transplanted into CCl4 injured mice. After two weeks of MSCs transplantation, mice were observed for liver regeneration. The morphological result showed that selenium treated MSCs have significant therapeutic effect in reduction of CCl4 induced injured as compared to untreated MSCs. Biochemical and histopathological result also revealed significant reduction in serum ALT and bilirubin level, collagen content in selenium treated .. View More»
  DOI: 10.4172/2157-7633.1000399

  Abstract PDF