Journal of Clinical & Experimental Pharmacology

Roy B

Publications

• Research Article
  Flowcytometric Analysis of Cell Cycle in the Liver of Mice in vivo Exposed to (+)-?-Viniferin, a Phytostilbene
  Author(s): Roy B and Pathaw DRoy B and Pathaw D
  
  In vitro anticancer and anthelmintic properties of the phytostilbene (+)-α-viniferin had been established. However, contradictory reports are available about the mode of action of the chemical. Therefore, an in vivo investigation was carried out to see whether or not the cell cycle arrest is the cause of cell death in the albino mice exposed to (+)-α- viniferin. Cell cycle was analysed in the liver cells of albino mice treated with different concentrations of the phytochemical, through flow cytometer. The results showed a constant dose dependent (1 mg to 5 mg (+)-α- viniferin/kg body weight of mice) increase in number of cells in the SubG1 stage of cell cycle along with a steady decrease in the number of cells in G0/G1 phase. Thus no cell cycle arrest was evident in any phase of cell cycle in the mice exposed to different concentration of (+)-&alpha.. View More»
  

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