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Journal of Data Mining in Genomics & Proteomics

Journal of Data Mining in Genomics & Proteomics
Open Access

ISSN: 2153-0602

Roger S Holmes

Roger S Holmes
Griffith Institute for Drug Discovery and School of Natural Sciences,
Nathan, QLD
Australia

Publications
  • Research Article
    Vertebrate Arylsulfatase K (ARSK): Comparative and Evolutionary Studies of the Lysosomal 2-Sulfoglucuronate Sulfatase
    Author(s): Roger S HolmesRoger S Holmes

    Arylsulfatase K (ARSK) is one of 17 sulfatase gene family members encoded on the human genome for which a role has been recently identified as a lysosomal 2-sulfoglucuronate sulfatase. Vertebrate ARSK sequences shared 60-82% identity but only <27% identities with other arylsulfatase family members. Comparative enzyme structures were studied, including residues with predicted roles in forming N-glycosylation sites, Ca2+ binding and active site residues. Vertebrate ARSK genes usually contained 8 coding exons. A human ARSK gene promoter comprised CpG61 and multiple TFBS, which may be involved in signal transduction, transcription activation or regulating entry into cell division. Phylogenetic analyses examined evolutionary changes for the vertebrate ARSK and the invertebrate SUL1 genes. In summary, a major role for this enzyme as a 2-sulfoglucuronate sulfatase is supported which has b.. Read More»
    DOI: 10.4172/2153-0602.1000212

    Abstract PDF

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