Journal of Data Mining in Genomics & Proteomics

Roger S Holmes

Publications

• Research Article
  Mammalian Glutamyl Aminopeptidase Genes (ENPEP) and Proteins: Comparative Studies of a Major Contributor to Arterial Hypertension
  Author(s): Roger S Holmes, Kimberley D Spradling-Reeves and Laura A CoxRoger S Holmes, Kimberley D Spradling-Reeves and Laura A Cox
  
  Glutamyl aminopeptidase (ENPEP) is a member of the M1 family of endopeptidases which are mammalian type II integral membrane zinc-containing endopeptidases. ENPEP is involved in the catabolic pathway of the reninangiotensin system forming angiotensin III, which participates in blood pressure regulation and blood vessel formation. Comparative ENPEP amino acid sequences and structures and ENPEP gene locations were examined using data from several mammalian genome projects. Mammalian ENPEP sequences shared 71-98% identities. Five N-glycosylation sites were conserved for all mammalian ENPEP proteins examined although 9-18 sites were observed, in each case. Sequence alignments, key amino acid residues and predicted secondary and tertiary structures were also studied, including transmembrane and cytoplasmic sequences and active site residues. Highest levels of human ENPEP expression were ob.. View More»
  DOI: 10.4172/2153-0602.1000211

  Abstract PDF